The best management for intensely radioactive isotopes that have very short half-lives is:

The management of intensely radioactive isotopes with very short half-lives is best achieved by isolating them from human contact during their acute phase. This approach is effective because these isotopes emit significant radiation shortly after they are produced. Their short half-lives mean that they will decay quickly, reducing their hazardous nature over time. By ensuring that they are isolated from any human interaction during this critical period, the risks associated with immediate exposure to radiation are minimized.

This strategy acknowledges the need for safety precautions in handling these materials and recognizes their transient hazardous nature. Moreover, once the isotopes have decayed to a level that is no longer considered dangerous, they can be handled or disposed of with reduced risk to public health.

The other management strategies, while they may offer some level of containment or safety, are not as appropriate for this specific scenario because they do not take into account the rapid decay of these isotopes. For instance, sealing radioactive materials in concrete and burying them may not be effective in the short term when immediate risks are present, and burying in specialized locations away from human habitats might not prevent potential exposure during the acute phase of radioactivity. Stopping production of machines that utilize these isotopes may not address existing materials already in use or stored