The disease that is commonly associated with stone age spearhead markers and sand blast operators is:

Silicosis is an occupational lung disease that arises from the inhalation of crystalline silica dust, which is common in environments such as mines, foundries, and workplaces involving sandblasting. The reference to "stone age spearhead markers" relates to historical artifacts made from silica-based materials, emphasizing the long-standing connection between silica dust exposure and respiratory disease. Workers in industries that perform sandblasting operations are particularly at risk for silicosis due to the significant amounts of silica dust present in the air they breathe.

The disease is characterized by inflammation and scarring of lung tissue after prolonged exposure to silica, leading to symptoms such as cough, difficulty breathing, and increased susceptibility to infections. Recognizing silicosis in the context of specific occupational exposures, such as those mentioned, aligns with the understanding of how certain jobs can lead to specific health risks associated with inhaling harmful substances. This makes silicosis the correct answer to the question regarding the disease linked with those particular occupational hazards.