Which regulation requires the development and maintenance of an exposure control plan?

The regulation that mandates the development and maintenance of an exposure control plan is OSHA's bloodborne pathogens regulations. These regulations are designed to protect employees from health hazards related to bloodborne pathogens, which include a variety of microorganisms present in human blood and other potentially infectious materials.

The exposure control plan is a crucial element of these regulations, as it outlines the necessary steps and protocols to minimize occupational exposure to these pathogens. This includes identification of employees at risk, implementing methods of compliance such as safety measures and work practices, and providing necessary training and vaccination to enhance workplace safety.

In contrast, the other options focus on different areas of regulation. For instance, EPA's biomedical waste regulations deal with the management and disposal of biomedical waste, which, although important for safety, do not specifically require an exposure control plan. USDA/APHIS plant genetics regulations pertain to the control and inspection of genetically modified organisms, and FIFRA is related to the regulation of pesticide usage, neither of which involves the same standards for managing bloodborne pathogens.